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It is contraindicated in people with cardiovascular disease such as uncontrolled high blood pressure, coronary artery disease, arrhythmias, or heart failure, as well as hyperthyroidism, and it should not be used within 14 days of a monoamine oxidase (MAO) inhibitor, among other cautions

Most patients begin on a low starting dose and gradually move up based on tolerance and weight loss response

Consuming a diet high in refined sugars, saturated fats, and processed foods is a significant contributor to Type 2 Diabetes

and because it tells cells everywhere to grow, prolonged misuse is linked to fluid retention, joint pain, enlargement of organs (acromegaly-type effects), and a theoretical increase in cancer risk (Liv Hospital)

Even so, extensive human research is still vital