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Cell Reports (2018) 10.1016/j.celrep.2018.05.054 Follow-up study showing that p53 mutations (common in cancer cells) confer resistance to FOXO4-DRI, highlighting the p53-dependent mechanism and the importance of functional p53 for the senolytic effect

Some individuals report subjective improvement within days of initiating protocols

Aside from genetic variations that may be causative factors in diabetes, individual patient attributes that influence how well a given medication works have major impact on personalized diabetes care

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It also markets Trulicity (dulaglutide) for type 2 diabetes