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Long-term administration of berberine increases the expression of IL-1 and inducible nitric oxide synthase (iNOS) in Alzheimers disease mice hippocampus, and ameliorate memory impairment (Zhu and Qian, 2006)

The ideal dosage varies, but most treatments range between 600 and 1200 mg per session

Mol Genet Metab 67:283293

The observed inconsistencies across studies likely result from variations in sample sizes, ethnic backgrounds, and age groups

By capturing patient-specific genetic and physiological features absent in immortalized cell lines, aOoCs allow more accurate evaluation of individual drug sensitivity and toxicity, providing a strategic avenue to accelerate and refine therapeutic development