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Moderate-severe steatosis was evident from 12 weeks and all mice demonstrated advanced steatosis (score 3) from 24 to 36 weeks followed by a gradual decline in NAS explained by reduced steatosis score from 48 weeks and onwards (Figs

doi:10.1038/s41392-023-01481-w Neumaier F, Zlatopolskiy BD, Neumaier B

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You may notice improvements in blood glucose within the first few weeks, but full effect is usually seen after 3 to 6 months once the maintenance dose is reached

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