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The same technology was used to develop a brain-targeting liposome formulation of doxorubicin

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Reaction mechanism [edit] GPX4 catalyzes the following reaction: 2 glutathione + lipidhydroperoxide glutathione disulfide + lipidalcohol + H 2 O This reaction occurs at the selenocysteine within the catalytic center of GPX4

However, dependent upon the degree of lyonization, and the degree to which the abnormal G6PD variant is expressed, the mean red blood cell enzyme activity in females may be normal, moderately reduced, or grossly deficient