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Reaching that target matters enormously because it significantly reduces the risk of diabetes-related complications including neuropathy, retinopathy, and kidney disease

During the formation of the pancreatic bud RFX6 expression declines in the PDX1 + /NKX6.1 + pancreatic progenitors but continues in the developing NGN3 + endocrine progenitor population

These include metabolic processes, protein folding (through its ability to form disulfide bonds), and detoxification pathways [33, 34]