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( Pharmaceuticals , 2026) reviewed BPC-157 in Achilles tendon repair and muscle-to-bone healing, with proposed mechanisms involving EGR-1 gene upregulationa transcription factor important in tendon and ligament repair

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One involves the secretion of cytotoxic granules containing perforin and granzyme, while the other triggers apoptosis through death receptor pathways by expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and/or Fas ligand (FasL)

Multiple studies have demonstrated that MSC-Exos attenuate ferroptosis in chondrocytes by targeting key molecular axes

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