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If your body develops antibodies against semaglutide fragments, it might start neutralizing even fresh, fully potent medication

10.3389/fnut.2023.1099880 40 MonamiM.MarchionniN.MannucciE

Working with a registered dietitian familiar with these medications can provide personalized guidance that balances symptom management with nutritional adequacyparticularly important for patients on these medications long-term for obesity management

Safety Signals in Phase II While efficacy was impressive, the trials also raised important safety concerns: Heart rate increases: Mean increases of 7.4 bpm (0.5 mg) and 9.1 bpm (1.0 mg) versus placebo Blood pressure: Modest systolic increases at higher doses Psychiatric effects: Insomnia (2135%), dry mouth (3044%), and mood changes in some patients Gastrointestinal: Nausea, diarrhea, and constipation at rates above placebo The cardiovascular signal particularly the heart rate increase would become the central obstacle in tesofensine's regulatory path

J Am Med Inform Assoc