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With efficacy largely proven, and both outcomes and side effects looking similar, the next phase will focus on affordability, accessibility, and how treatments fit into patients' lives

Huang L, Zhang F, Xu P, Zhou Y, Liu Y, Zhang H, et al

Given the absence of recurrence up to now, 24 months postoperatively, it remains uncertain in which cases immediate adjuvant therapy is needed

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Additionally, gastrointestinal side effectsnausea, constipation, or vomitingcause some people to remain on lower maintenance doses that produce 10-15% weight loss rather than the 22% maximum-dose result