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Glutathione is produced naturally in the body, but its levels can deplete due to ageing, stress, poor diet, and exposure to toxins

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Duperray, J., Sergheraert, R., Chalothorn, K., Tachalerdmanee, P., & Perin, F

In general, it is assumed that the two main limiting factors are the levels of cysteine and of the enzyme gamma-glutamyl-cysteine synthetase (also known as glutamate-cysteine ligase)