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Steroids can increase appetite while semaglutide suppresses it, creating an unpredictable net effect

doi: 10.1002/nbm.1512 396 MathewSJMaoXKeeganKALevineSMSmithELHeierLAet al

While many drugs in this class were initially approved to treat type 2 diabetes, they have also been approved for weight loss

At the time of the terminal experiments, hemodynamic measurement was performed by using a Mikro-Tip catheter (SPR-407, Millar Instruments, Houston, TX) to obtain left ventricular end-diastolic pressure (LVEDP), left ventricular end-systolic pressure (LVESP), heart rate, maximal slope of systolic pressure increment (+dP/dt) and diastolic pressure decrement (dP/dt)

Two of the field-defining dihexa papers from the Journal of Pharmacology and Experimental Therapeutics were formally retracted in April 2025 for falsified and fabricated image data, with the retraction attributing the misconduct to Leen Kawas and James Harding (retraction record