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Age is another important factorolder adults naturally experience sarcopenia (age-related muscle loss) and may be more vulnerable to further muscle decline during pharmacologically induced weight loss

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In February 2026, researchers concluded that weight loss drugs containing tirzepatide may help lower the risk of eye disease in people with type 2 diabetes.

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While there are no randomized trials specifically testing probiotics for retatrutide-related diarrhea, the mechanistic rationale is strong

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