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Inhibiting the activity of system Xc affects GSH synthesis by inhibiting cystine absorption, leading to decreased GPX activity, reduced cellular antioxidant capacity, accumulation of lipid ROS, and ultimately oxidative damage and ferroptosis
It acts as an antioxidant by neutralizing free radicals and reactive oxygen species (ROS), preventing them from causing harm to cellular structures such as DNA, proteins, and lipids
Reported side effects appear relatively mild and may include temporary injection site reactions when administered subcutaneously, mild headaches, or transient fatigue
It included subjects with NAFLD, who were or were not obese, and evaluated if, and how, their plasma amino acids were altered, and the relationship with insulin resistance
Alcohol consumption while taking Wegovy can increase the risk of side effects such as nausea, vomiting, and low blood sugar
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