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In animal studies, in comparison to a control diet, HFD consumption resulted in increased hepatic IKK--SSG formation, leading to suppressed IKK- activation and subsequent NF-B suppression

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The NPs and MNs groups did not significantly improve these indicators, while the GLP-1RAs@NPs, GLP-1RAs@NPs-WYRGRL and MNs/GLP-1RAs@NPs-WYRGRL groups could significantly up-regulate the expression of GLP-1R and down-regulate the expression of STING, ACSL4 and TNF-

doi: 10.1016/j.fufo.2023.100271 44 MurugesanSMaranPVenkatesanMAlexanderRA