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In addition, FIN56 is capable of binding and activating squalene synthase, and leads to depleting coenzyme Q10 (CoQ10) (Shimada et al., 2016), which is a vital antioxidant by directly reducing lipid peroxyl radicals ( 2 , which is able to oxidate iron and indirectly inactivate GPX4, thus inducing lipid peroxidation in an ALOX-independent manner ( Connection Although the majority of current research regarding ferroptosis has focused on malignancies and degenerative diseases, there remain a few investigations on ferroptosis in cutaneous diseases