Mechanistically, calcitriol upregulates key lipid-synthesizing enzymesincluding fatty acid synthase (FAS), 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase), and serine palmitoyltransferase (SPT)and promotes lamellar body maturation and secretion, thereby enhancing stratum corneum structural cohesion [234,235,236]
Martini WZ, Xia H, Ryan KL, Bynum J, Cap AP
Data are available, however, from the corresponding author upon reasonable request and with permission of Baylor University and Kyowa Hakko Bio Co., Ltd
GSH was found present in the cell lysate of Lb
Management The cornerstone of DILI management lies in early identification and prompt withdrawal of the offending agent