While side effects are often cited as a reason for GLP-1 non-adherence, the gap in persistence for the same molecule reflects deeper behavioral and systemic challenges
Its deeply tied to: Cortisol levels (stress hormone) Estrogen/testosterone ratios Insulin sensitivity and blood sugar regulation Age and inflammation When you begin to lose weight, your body often sheds subcutaneous fat first especially in areas that arent hormonally protected. But belly fat stays because your body thinks you might need it later
Christoffersen B, Sanchez-Delgado G, John LM, Ryan DH, Raun K, Ravussin E (2022) Beyond appetite regulation: targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss
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Furthermore, post hoc subgroup analyses of cardiovascular outcome trials have suggested a greater cardiorenal protection in patients treated with a combination versus either monotherapy