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UPDRS motor score change from baseline was evaluated using time to clinically relevant response, response duration, area under the curve, maximal response, and time to maximal response

In addition, low IGF-1 subjects in a study were found to possess up-regulated fatty acid metabolism along with down-regulated GLUT-1 gene (in charge of glucose uptake in erythrocytes, brain endothelial cells, eye, peripheral nerve and also responsible for materno-placental glucose transfer) [210]

These cellular sources include: Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs): These highly proliferative and neurotrophic stem cells secrete brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), improving synaptic plasticity and neuronal survival in regions linked to sleep regulation, such as the hypothalamus and brainstem

Red flags: You could also have more serious side effects that require urgent medical care