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Pharmacological inhibition of ER signaling attenuates ferroptosis, providing mechanistic insight into the sexual dimorphism observed in asthma prevalence and severity, where premenopausal females often exhibit higher disease burden

Based on urine studies, compounds like phenylpyruvate and phenylacetate have been proposed as more efficient markers for disease than direct measurement of phenylalanine, given ease of obtaining urine samples and a low false-negative diagnostic rate (54)

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