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Additional illustrative linker intermediates (also referred as folate spacers) are described herein: EC 014 EC0014: 1H NMR (D 2 0, 500 MHz) 5(ppm) 8.73(s, IH, FA H-7), 7.56 (d, 2H, FA H-12&H16), 6.73(d, 2H, FA H-13&H15), 4.45(m, 2H), 4.1(m, 2H), 3.61(d, 2H), 2.82(m, 3H), 2.74(dd, IH), 2.37(m, 2H), 2.18(m, IH), 2.09(m, 3H), 1.74(m, IH) EXAMPLE Pte-y-D-Glu- -Dap-Asp-Cys EC0020: MS (ESI, [M+H] + ) 746

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Immunohistochemical staining Formalin-fixed kidneys were embedded in paraffin, and 4-m sections were cut by the Barts Cancer Institute Pathology Unit

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