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These reductions appear to result from weight loss, improved insulin sensitivity, and potentially increased sodium excretion

Most clinicians start with a detailed medication and health review, then order targeted tests to set a baseline and catch contraindications

Food and Drug Administration Wegovy (semaglutide) prescribing information Official dosing, administration, and safety labeling Medication Manufacturer Instructions Novo Nordisk Wegovy Injection Instructions Official injection technique and pen usage Eli Lilly and Company Mounjaro (tirzepatide) Instructions for Use Proper administration and dosing schedule Evidence-Based Research New England Journal of Medicine Once-Weekly Semaglutide in Adults with Overweight or Obesity Landmark clinical trial demonstrating weight loss outcomes National Institutes of Health GLP-1 receptor agonists for obesity treatment Mechanism and long-term effectiveness