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These natural agents not only mitigate hepatic damage but also provide immune modulation and chronic disease management

HDACs participate in regulating immune cell function and maintaining immune homeostasis through their effects on conformation, transcription factor activity, and downstream inflammation-related gene expression, which renders them a crucial potential target for RA treatment

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(2003) 61 Suppl 1:S9S18

Numerous studies have demonstrated that E2 exerts an inhibitory effect on HIF-1 expression (17, 28, 68), aligning with the mechanisms through which OSAHS induces cellular autophagy, suggesting that E2 may modulate autophagy via the HIF-1 pathway