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861 Menopause is a risk factor for OA, and epidemiological studies have found that postmenopausal women have a rapidly increased risk of osteoarthritis compared to premenopausal women of the same age, indicating that estrogen level is a key factor in OA development

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It is also important to ensure adequate intake of vitamin B12 and B6 , which collaborate with vitamin B9 in the methylation cycle and may help to minimize the adverse effects of reduced metabolism due to decreased MTHFR enzyme activity