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Moreover, a diminished ferroptosis activation threshold might be present in trophoblast cells with increased vulnerability in the presence of low-dose exposure to RSL3 [123]

The outcome depends on curcumin dose, formulation (particularly whether piperine is included), baseline blood pressure, and whether other CYP3A4-modulating drugs are on board

Dysregulation of these pathways contributes to impaired insulin secretion, altered lipid homeostasis, hyperglycemia, and metabolic dysfunction observed in obesity and type 2 diabetes [1]

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