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Wu B (2012) Pharmacokinetic interplay of phase II metabolism and transport: a theoretical study

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However, these increases were time dependent, and the levels returned to normal after about 1 month

A large trial reported in 1994 (pdf) that daily megadoses of the antioxidant beta-carotene increased the risk of lung cancer in male smokers by 18 percent and a 1996 trial was stopped early after researchers discovered that high-dose beta-carotene and retinol, another form of vitamin A, increased lung cancer risk by 28 percent in smokers and workers exposed to asbestos

Bradyarrhythmia can be physiologic, without symptoms or hemodynamic change