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It is also worth noting that SGLT2 inhibitors another class of medicines with powerful cardiovascular and kidney benefits, are often used alongside or as an alternative to GLP-1 agonists in patients with type 2 diabetes and heart disease

As long as the vial seal remains intact, refrigeration offers no additional benefit and may even introduce risk

Pharmacokinetics of tirzepatide demonstrated dose proportionality over the wide dose range, with C max of 180 nM in individuals treated with one dose of 8 mg and a C max of 260 nM with 15 mg/week dose in the clinical study, exceeding the EC50 values for GIPR and GLP-1R activations by approximately 10,000-fold and 250-fold, respectively (63)

We emphasize the importance for our providers to go over all of your options during your free expert consultation

doi: 10.1016/j.pharmthera.2017.11.006