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Users guide to mechanism of action and clinical use of GLP-1 receptor agonists

[88] In March 2026, the CHMP recommended granting a conditional marketing authorization for Kayshild (semaglutide), a GLP-1 receptor agonist for the treatment of non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with liver fibrosis, a serious disease where fat deposits accumulate in the liver causing inflammation

Its important to note that while semaglutide GLP-1 significantly reduces appetite, it does not eliminate hunger entirely

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