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Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, which occur in approximately 16-44% of patients depending on the product and dose according to clinical trials

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Bowel Obstruction: Studies show a link between Trulicity and an increased risk of bowel obstruction, particularly for those new to the medication (had been taking the drug for less than one month)

Timing your injection for minimal side effects The best time of day to inject semaglutide varies by individual, but most people find that injecting in the evening or before bed minimizes the impact of any post-injection nausea