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(a) miR-320d expression assessed by qPCR, normalized to housekeeping gene RNU48 and expressed as fold induction compared to mimic control (2Ct)

This condition manifests through intense cravings, withdrawal symptoms when attempting to quit, tolerance development requiring increased consumption, continued use despite awareness of health risks, difficulty controlling or stopping use, and significant impacts on daily functioning and relationships leading to long-term health complications if left untreated