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Considering the specific safety concerns, contraindications (for example, bupropion is contraindicated in patients who have seizures) and comorbidities, the choice of agent is based largely on patient preference after discussion with a clinician [footnote 53]

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Yor (Petitioners) do therefore humbley pray your Exncy that our time of stay for the dispatch of our necessary Business (for the Intrest as well of the Masters as our Owners) may be lengthened untill the last day of June that at which time wee do all Sincerely promise to be all ready loaden or unloaden at Kiquotan to set Sayle under Convoy of Capt Crowe the Commandore aforesaid