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"Nicotine, although not a carcinogen itself, is highly addictive and can enhance the appeal of tobacco products."

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Clinical trials investigating these interventions are needed to assess their efficacy in preventing or treating smoking-related diseases, such as periodontitis, COPD, and cancer

Many studies have additionally associated nicotine addiction with social factors, with group acceptance and social status playing a pivotal role in developing a smoking habit

Nevertheless, French politicians braved the smoking backlash and pushed through plain packaging legislation, which came into force in France on May 20, 2016