Rogan and Jacobsen examine user-reported effects: | Effect | Reported Frequency | Mechanism | |---|---|---| | Skin darkening | Universal | Stimulates melanocytes to produce melanin | | Spontaneous erections | Common in men with ED | Stimulates melanocortin receptors (MC4R) in the brain involved in sexual arousal | | Increased libido | Majority of users | Same MC4R pathway | | Hair color change (darkening) | Anecdotal (single case report) | Melanin repigmentation of hair follicles | | Nausea, yawning, flushing | Common at higher doses | Off-target receptor activation | | New or darkened moles | Reported | Potential masking of melanoma | Jacobsen notes a critical physiological nuance: melanin produced via injection may not migrate to the correct location in the skin
For example, it's stated that Mancera perfume boxes have special embossing, but as far as I know, this isn't a problem for illegal businesses
Cigarettes made with lighter burley tobacco became popular, especially among men who served in World War I, sapping dark-fire chaw profits
Straightforward value, no surprises
Acetone was identified, not quantified in the emissions of new carpets(3), automobiles(4,5) and common household waste(6-9)
