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Monographs on the Evaluation of Carcinogenic Risks to Human, 92 Lyon, France: IARC, 2010

Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers

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If, for instance, you were interrupted and couldnt finish your cigar, simply let it extinguish itself