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[ 65 ] In California localities that had a strong tobacco retailer license, a 2014 study showed that youth were 26% less likely to initiate e-cigarette use and 55% less likely have become a current e-cigarette user over the course of 1.5 years compared to localities that had no licensing law or did not have a licensing fee high enough to cover the costs of enforcement
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For females the comparison is quite different: 48.1% of countries have lower female daily smoking prevalence than the lowest daily smoking prevalence in any county in the US
This suggests that users who consume BQ with tobacco may experience combined effects from both arecoline and tobacco-derived MAO inhibitors, which could significantly influence addiction mechanisms and cessation strategies (Figure 3)
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