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DO NOT expose to water, extreme heat, or direct sunlight

On average, each cigarette contains roughly 10-12 milligrams (mg) of nicotine, or about 6 mg on the low end and 28 mg on the high end

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After 2 weeks of usual treatment with a 21-mg patch, participants who fail to quit smoking (target n = 400) will be randomized to receive escalating doses of a nicotine patch vs matching placebo patches for an additional 10 weeks or up to a maximum dose of 84 mg per day