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He also noted that minors who have not been exposed to smoking will be less likely to develop the unhealthy habit

The minimum tobacco age limit was recently raised from 18 years old to 21 years old to align with federal law

(2) C-Store Dive, "Tracking Buc-ee's US Expansion," updated March 2026

The key protein molecules and signaling pathways involved include: It has been demonstrated that nuclear receptor subfamily 4 group a member 1 (NR4A1) (Zhu et al., 2022a), AMPK/Nrf2 pathway (Yang et al., 2022), and cytoplasmic phospholipase A2 (cPLA2)/prostaglandin E2 (PGE2) signaling pathway (Han et al., 2023) can mediate mitochondrial dynamics

Apollonio Reference Apollonio, Philipps and Bero2016)