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revealed that both tobacco and electronic cigarette inhalation significantly increased markers of oxidative stress (sNox2-dp, H2O2, and 8-iso-PGF2a levels) and platelet activity (sCD40L and soluble P-selectin), and decreased markers of NO bioavailability and antioxidants (Vitamin E) in tobacco smokers classified as healthy (23), Similarly, Mobarrez et al

That's down slightly from 2017, though the change is not statistically significant

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The crucial question here is safe compared to what

The first are people for whom menthol primarily serves to reduce the harsh effects of smoke