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Understanding how nicotine works helps to understand why nicotine replacement therapies (such as patches, gum or lozenges) are designed in this way: to provide controlled, lower doses of nicotine at a slower rate of delivery and without the toxic chemicals found in cigarette smoke

Alcohol and blood pressure and its interaction with smoking and other behavioural variables: results from the MONICA Augsburg Survey 19841985 J Hypertens 1991 9 : 491498 Berglund G, Wilhelmsen L

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These are typically used in the processing of Burley tobaccos and in several pipe tobaccos