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Very few studies have shown an uptake of supplemental carnitine into muscle, but the limited evidence suggests a large dose of carbohydrate (80g with each dose) is required over at least 12 weeks in order to achieve this

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Only the L-isomer of carnitine is biologically active

Specifically, neuropeptide Y/agouti-related protein (NPY/AgRP) neurons control appetite by the orexigenic effect47), and pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons are sensitive to peripheral hormones such as insulin and leptin by anorexigenic effects48)