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However, the way each persons body metabolizes nicotine to create cotinine is different

Department of Health and Human Services, Smoking Cessation: A Report of the Surgeon General, 2020

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Under this e-cigarettes and refill containers cannot be directly or indirectly advertised or promoted: on TV or on-demand TV on radio through information society services (for example internet advertising and commercial e-mail) in certain printed publications (for example newspapers, magazines and periodicals) This also prohibits e-cigarette product placement or any sponsorship promoting e- cigarettes on radio and TV programmes

The combination of these substances may lead to an intensified cardiovascular response, potentially causing strain on the heart