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[1] [2] The medication works through a dual mechanism of action as both a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

Glutathione, a natural substance found in varying degrees in all cells, tissues, organs, systems, and fluids in the body

Both Epac1 and Epac2 are expressed in the pancreas (Leech et al., 2000), and under high glucose conditions, Ca 2+ flows into cells through VDC channels, and Epac2 opens RYR calcium channels in the endoplasmic reticulum, further increasing intracellular Ca 2+ concentrations and enhancing exocytosis of insulin-secreting vesicles (Holz, 2004

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