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Phase 2 results: the clinical foundation The Phase 2 trial, published in the New England Journal of Medicine in June 2023, remains the most detailed dataset available, and the primary source for dose-specific results at doses below 9mg

Cyanocobalamin (B12) plays a critical role in energy metabolism by aiding in the formation of red blood cells, supporting nerve health, and facilitating DNA synthesis

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Exposure per milligram is higher, particularly in lighter East Asian users, while the smaller fat reserve makes a 75:25 fat-to-lean split more consequential

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