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Foi isolado pela primeira vez do plasma humano no incio da dcada de 1970 pelo bioqumico Loren Pickart, que observou que o plasma humano mais velho havia perdido certas propriedades regenerativas presentes no plasma jovem, e atribuiu essa atividade a essa pequena molcula ligante de cobre

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PGE-1 is a substance that in fact improves the microcirculation and leads to the development of collateral circuits with a consequent improvement in local hemodynamics

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