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Volkow ND, Swanson JM, Evins AE, et al

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Nicotine withdrawal increases stress-associated genes in the nucleus accumbens of female rats in a hormone-dependent manner

Similar content being viewed by others Background Oral cancer represents a significant public health challenge, ranking as the leading cancer in males and the third most prevalent in females in Pakistan.[1] The persistent and extensive consumption of smokeless tobacco (SLT) products is demonstrably linked to this serious health outcome, translating into a significant loss of disability-adjusted life years (DALYs) and a heightened risk of cardiovascular mortality.[2] Based on the estimates from the Global Burden of Disease 2019 study, Pakistan has the highest ASIR (Age-Standardized Incidence Rate) and age-standardized DALYs (Disability-Adjusted Life Years) for oral cancer among Asian countries

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