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In terms of immune modulation, GLP-1RAs demonstrate a bidirectional mechanism: they can enhance anti-tumor immune responses while modulating systemic inflammatory processes

The exploding popularity of this drug makes it imperative to understand all its potential complications, says co-author Dr

The main adverse events were associated with the gastrointestinal tract (11.6% oral semaglutide versus 6.5% placebo) and were responsible for discontinuing treatment in 6.8% of patients treated with oral semaglutide and 1.6% of those who received placebo [44]

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Butyrate has been shown to reverse the abnormal expression of ZO-1 and reduce LPS translocation as well as inhibit macrophage activation, pro-inflammatory cytokine production, and neutrophil infiltration, thereby reducing liver injury in rats (105)