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Pharmacological and toxicological studies support the biological plausibility that nicotine contributes to acute cardiovascular events and accelerated atherogenesis

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The slow formation of atherosclerotic plaque is mostly asymptomatic, but plaque rupture or endothelial erosion will trigger thrombosis, leading to an atherothrombotic occlusion [104, 106]

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"We try to study as much as we can, but it's difficult because as soon as we publish our results, this product we've been analysing has either been modified or is no longer on the market," he says