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Vaping cannabis on three or more days in the past 30 days was associated with twice the risk of wheeze, and with experiencing whistling in ones chest during the past year which is a high-pitched sound that, when heard while breathing, can indicate that your airways have narrowed or become inflamed

A flavoring agent called diacetyl, for example, has been linked to a serious lung disease (see below)

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Through its activation of nAchRs nicotine also indirectly activates dopaminergic and glutamatergic receptors and systems 47,48