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[16] Hematinic deficiencies (vitamin B12, folic acid and iron), occurring singly or in combination, [8] and with or without any underlying gastrointestinal disease, may be twice as common in people with RAS

Contrast the chromosomes of a non-smoker ( left ) and a smoker ( right )

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There are a number of prescription and over-the-counter medications that can worsen GERD symptoms, like NSAIDs (ibuprofen, aspirin, naproxen, diclofenac, and more), antibiotics, potassium and iron supplements, narcotics, progesterone, sedatives, and some antidepressants