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Given that COPD is an inflammatory airway disease driven by CS, then in the case of asthma, we can speculate that CS may contribute to asthma having features of COPD or manifesting as ACO, causing further aggravation of airway inflammation 49

La bronchite chronique obstructive : - s'installe aprs une dizaine d'annes de tabagisme, - traduit une atteinte plus importante des petites bronches, - peut tre dcele par simple spiromtre (baisse du VEMS), - provoque une dyspne perue par le fumeur l'effort

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