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A large, multicenter randomized controlled trial of nicotinamide in ICA-positive siblings (ages, 3-12 years) of type 1 diabetic patients also failed to find a difference in the incidence of type 1 diabetes after three years (70)

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Both TLR9 and cGAS-STING pathways lead to increased cytokine synthesis, particularly interleukin-6 (IL-6) and interleukin-8 (IL-8) ( 33 )

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